Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration
نویسندگان
چکیده
منابع مشابه
Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration.
THE ROLE OF Na-K-ATPase in the regulation of epithelial cell polarity, adhesion, and migration has been demonstrated. Some of these processes, such as tight junction (TJ) formation, require ion transport function of Na-K-ATPase by its catalytic subunit Na-K. Other functions, such as motility suppression, cell adhesion, and contact inhibition, are mediated by the regulatory subunit Na-K, typical...
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Tight junctions are unique organelles in polarized epithelial and endothelial cells that regulate the flow of solutes and ions across the epithelial barrier. The structure and functions of tight junctions are regulated by a wide variety of signaling and molecular mechanisms. Several recent studies in mammals, drosophila, and zebrafish reported a new role for Na,K-ATPase, a well-studied ion tran...
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We evaluated the effects of keratinocyte growth factor (KGF) on alveolar epithelial cell (AEC) active ion transport and on rat epithelial Na channel (rENaC) subunit and Na+-K+-adenosinetriphosphatase (ATPase) subunit isoform expression using monolayers of AEC grown in primary culture. Rat alveolar type II cells were plated on polycarbonate filters in serum-free medium, and KGF (10 ng/ml) was ad...
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The Na,K-adenosine triphosphatase (ATPase), or sodium pump, has been well studied for its role in the regulation of ion homeostasis in mammalian cells. Recent studies suggest that Na,K-ATPase might have multiple functions such as a role in the regulation of tight junction structure and function, induction of polarity, regulation of actin dynamics, control of cell movement, and cell signaling. T...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2015
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00140.2015